What is Rugiet Ready™ Troche?

Rugiet Ready™ Troche is a compounded dissolvable tablet combining three active ingredients: sildenafil, tadalafil, and apomorphine. It is intended only for men 18 years and older for the treatment of erectile dysfunction.

Important: Rugiet Ready™ Troche is a compounded medication. Although its ingredients have been FDAapproved for other uses, Ready™ Troche itself is NOT FDA-approved and has not been reviewed by the FDA for safety, effectiveness, or quality for any use.

Ready™ Troche is not intended for regular/daily use. Do not stop taking this medication suddenly if you have been using it regularly. Rapid dose reduction can cause a serious withdrawal syndrome characterized by fever and confusion.

• Sildenafil and Tadalafil are PDE5 inhibitors FDA-approved to treat erectile dysfunction.
• Apomorphine works on dopamine receptors in the brain to help with erections.
  

Note: This summary does not contain all possible safety information. It is not a substitute for advice from your healthcare provider. Always talk to your doctor or pharmacist before taking this medication.

How to Take Rugiet Ready™ Troche

1. Take one tablet 15-30 minutes before planned sexual activity (30 minutes is recommended for best results).
2. Place the tablet under your tongue and allow it to fully dissolve. DO NOT CHEW OR SWALLOW.
3. As the tablet dissolves, the medication is absorbed directly into your bloodstream for faster results than swallowing a pill.
4. The medication will not work unless you are sexually aroused.

Important Usage Notes

• Maximum dose: One dose every 24 hours
• How long it lasts: Effects typically last 24-36 hours (tadalafil can remain in your system for up to 36 hours)
• Kissing: Wait at least 10 minutes for the tablet to completely dissolve before kissing to avoid passing medication to your partner
• Storage: Keep in a cool, dry place at room temperature
• STI Protection: This medication does NOT protect against sexually transmitted infections (including HIV/AIDS). Use appropriate protection.

Who Should NOT Take Rugiet Ready™ Troche

Do not take Ready™ Troche if you:

• Are taking any form of nitrates (such as nitroglycerin, isosorbide mononitrate, or isosorbide dinitrate) for chest pain or heart conditions
• Are using "poppers" (amyl nitrite or butyl nitrite)
• Are taking guanylate cyclase stimulators (such as riociguat or vericiguat) for pulmonary hypertension
• Are taking anti-nausea or IBS medications that block serotonin (5-HT3 antagonists), such as:
  • Ondansetron (Zofran)
  • Granisetron (Kytril)
  • Dolasetron (Anzemet)
  • Palonosetron (Aloxi)
  • Alosetron (Lotronex)
• Have a known allergy to sildenafil, tadalafil, or apomorphine
• Have been told by your doctor that sexual activity is not safe for you due to heart problems

Important Warnings

Heart and Blood Pressure Concerns

• Ready™ Troche can cause a dangerous drop in blood pressure, especially when combined with certain medications.
• Do not take Ready™ Troche if sexual activity is risky for your heart.
• Use caution if you take alpha-blockers or blood pressure medications—this combination may cause your blood pressure to drop too low, potentially causing fainting.

Heart Rhythm Warning

• Ready™ Troche may affect your heart rhythm (prolong the QT interval).
• Use with caution if you have been diagnosed with Long QT Syndrome or take medications that affect heart rhythm.
• In rare cases, this can cause a dangerous heart rhythm called torsades de pointes.

Vision and Hearing

• Stop taking Ready™ Troche and get medical help right away if you experience sudden vision loss in one or both eyes.
• Stop taking Ready™ Troche and get medical help right away if you experience sudden hearing loss or ringing in your ears.
• You may experience temporary blue-tinted vision or other visual changes.

Prolonged Erection

• Seek emergency medical care if you have an erection lasting more than 4 hours. This condition (priapism) can cause permanent damage if not treated promptly.

Mental Health and Behavioral Effects

• Use caution if you have been diagnosed with a major psychotic disorder, have a history of psychosis, or take antipsychotic medications.
• Ready™ Troche may cause hallucinations or affect behavior in some patients.
• This medication may affect impulse control and cause compulsive behaviors.

Drowsiness and Alertness

• Ready™ Troche may cause drowsiness or daytime sleepiness.
• Be careful when driving or operating heavy machinery.

Parkinson's Disease

• Use caution if you have been diagnosed with or are being treated for Parkinson's disease.

Other Precautions

Talk to your doctor before taking Ready™ Troche if you have:

• Kidney or liver problems
• Active stomach ulcers (peptic ulcers)
• A bleeding disorder
• A history of priapism (prolonged erections)

Cannabis Warning

Avoid concurrent use of cannabis products, as they may slow the breakdown of your medication and increase side effects.

Food and Drink Interactions

• Avoid grapefruit and grapefruit juice—they can increase medication levels in your blood
• Limit alcohol consumption—excessive alcohol can increase side effects and lower blood pressure

Drug Interactions

Tell your doctor about all medications you take, especially:

Always tell all your doctors that you are taking Ready™ Troche (sildenafil, tadalafil, and apomorphine administered under the tongue), especially before starting any new medications.

Common Side Effects

• Headache
• Flushing (warmth or redness)
• Skin rash
• Vision changes or blue-tinted vision
• Indigestion or upset stomach
• Irritation in the mouth (where tablet dissolves)
• Stuffy nose
• Dizziness
• Nausea
• Back pain
• Muscle aches

If any side effects become concerning, contact your doctor or call the
phone number on your prescription label to speak with a pharmacist.

When to Seek Emergency Medical Help

STOP taking Ready™ Troche and get immediate medical attention if you experience:

• Chest pain (Do NOT use nitrates to treat chest pain while on this medication)
• Palpitations (irregular or pounding heartbeat)
• Fainting
• Unusual weakness or pale/yellow skin (may be signs of a blood disorder)
• Hallucinations or unusual behavior
• An erection lasting more than 4 hours
• Sudden loss of vision or hearing
• Allergic reaction: sudden wheezing, difficulty breathing, dizziness, swelling of face/lips/tongue/throat, or hives
• Severe skin reactions: skin rash with severe blistering, peeling, pain, swelling, or blistering around the mouth, genitals, or eyes, especially with fever (may be Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis)