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Sildenafil and tadalafil are two common medications used for erectile dysfunction (ED) treatment, but is it safe to take them together? Hear from a men’s health expert on the benefits, potential drug interactions, and results real men have seen from combining sildenafil and tadalafil.
What is the difference between sildenafil and tadalafil?
Sildenafil (Viagra®) and tadalafil (Cialis®) are two common medications used to treat a range of health conditions, including symptom management of benign prostatic hyperplasia, pulmonary arterial hypertension, and most commonly, for ED treatment. (Tadalafil, 2023) (Sildenafil, 2023)
The key difference between the two medications is that tadalafil lasts longer (up to 36 hours after ingestion, compared to approximately 4 hours for sildenafil). (Kemper, 2024)
While there are some minor differences between the two medications, many researchers agree that tadalafil and sildenafil are similar in efficacy and safety, and both can significantly improve a patient’s sexual confidence. (Gong, B 2017)
How do sildenafil and tadalafil work?
Sildenafil and tadalafil are both PDE5 inhibitors, meaning they slow or stop the action of an enzyme found in the body known as phosphodiesterase 5. This leads to increased blood flow to the penis when a man is aroused, allowing for a more satisfactory erection. (Dhaliwal A, 2023)
It is worth noting that these medications don’t increase sexual desire, however, the addition of the dopamine agonist apomorphine (APO) has been shown to have positive effects on those struggling with psychogenic erectile dysfunction. (Ribaric S, 2012)
The benefits of compounded pharmaceuticals
Compounded pharmaceuticals involve combining and optimizing individual active pharmaceutical ingredients of popular medications for a more customized treatment.
There are many benefits to compounded pharmaceuticals-- as this 2022 study states, “Several therapeutic needs can be met by a compounded medicine such as dosing adjusted for pediatric patients, special drug combinations, medicines for patients allergic to a given excipient, and medicines for orphan drugs not provided by the pharmaceutical industry.” (Carvalho)
In simpler terms, stand-alone medications don’t always work for everyone-- in fact, monotherapy (using one medication) to treat ED doesn’t lead to results for 30-40% of patients. (Munk, 2019) It’s time for a better solution.
This is why Rugiet Health believes that the future of healthcare goes beyond cookie-cutter, mass-manufactured medications. We believe in tailoring treatment options according to each patient’s health priorities and feedback.
Remember to speak with a healthcare provider before taking any new medications or changing your prescribed treatment regime.
So, what happens when you combine sildenafil and tadalafil?
Multiple studies have shown that combining sildenafil and tadalafil can lead to effective, lasting, and superior results than with one stand-alone medication. (Cui, H, 2015) (Sullivan, JF, 2021)
A study published in The First International Journal of Andrology shows that "combined medication can better improve erectile function, especially for patients with severe ED". (Cui, H, 2015) Additionally, a systematic review agreed that “Tadalafil…may be an ideal agent to prescribe daily along with [sildenafil]”. (Sullivan, JF, 2021)
At Rugiet, we’ve combined three FDA-approved medications (sildenafil, tadalafil, and apomorphine) into one under-the-tongue dose, designed to bring your confidence back and help you regain your roar.
Rugiet Ready
Rugiet Ready is a prescribed, compounded medication, and a breakthrough treatment for ED that has quickly gained tremendous popularity in men’s health care.
Rugiet Ready’s inventor, Dr. Ken Bains, is taking ED medication a step further by pairing the powerful duo of PDE5 inhibitors, adding APO (a dopamine promoter that primes the brain for sexual arousal), and formulating it into a mint-flavored sublingual that dissolves under the tongue.
Our network of US-licensed physicians support our unique combination approach- and thousands of satisfied customers have seen impressive results.
Get a combination erectile dysfunction medication that actually works
To craft your custom ED combination, complete Rugiet’s online medical questionnaire that will connect you with a board-certified doctor in Rugiet Health’s network to evaluate your medical history and determine the right treatment for you. After you order, you can contact your doctor anytime you want through the Member’s Portal to ask a question, further customize your prescription, and more.
You should never change your medication routine or combine medications without speaking to a qualified healthcare professional. When you get started with Rugiet, your doctor will need to thoroughly evaluate your medical history to safely prescribe an appropriate combination treatment. Every doctor in the Rugiet Health network is board-certified, based in the USA, and committed to providing you exceptional care.
Many of our members report minimized (and eliminated) side effects thanks to the compounded ingredients in Rugiet:
“Talk with the Docs at Rugiet! Unlike Viagra with headache and stuffy nose had none of that! The 3rd ingredient worked synergistically and for me created desire! Impressed! Can feel effects and instant hardness for 24 hours or more!” -Logan C.
Join over 50,000 men who have already experienced the difference- try Rugiet today.
Listen to your doctor
Rugiet Health’s number one priority is the health and safety of our members. It is always necessary that you reach out to a medical professional before taking any new medications. Our network of board-certified Rugiet Health physicians is a great resource- get connected with a provider today.
DISCLAIMER: This article is the expressed opinion of Rugiet Health, and these statements have not been evaluated by the FDA. We have an unwavering commitment to maximizing safety and improving the quality of life for thousands of people all over America in more ways than one. We do not condone mixing any prescribed pharmaceuticals together without first consulting a qualified medical professional.
Citations:
U.S. National Library of Medicine. (2023, April 15). Tadalafil: Medlineplus drug information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a604008.html
U.S. National Library of Medicine. (2023, August 15). Sildenafil: Medlineplus drug information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a699015.html
Kemper, M. (2024, September 4). Comparing viagra / sildenafil vs Cialis / Tadalafil for ED. GA Urology. https://www.gaurology.com/comparing-viagra-sildenafil-cialis-tadalafil-for-ed/
Gong, B., Ma, M., Xie, W., Yang, X., Huang, Y., Sun, T., Luo, Y., & Huang, J. (2017). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International urology and nephrology, 49(10), 1731–1740. https://doi.org/10.1007/s11255-017-1644-5
Dhaliwal A, Gupta M. PDE5 Inhibitors. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK549843/
Ribarič S. (2012). The pharmacological properties and therapeutic use of apomorphine. Molecules (Basel, Switzerland), 17(5), 5289–5309. https://doi.org/10.3390/molecules17055289
Carvalho, M., & Almeida, I. F. (2022). The Role of Pharmaceutical Compounding in Promoting Medication Adherence. Pharmaceuticals (Basel, Switzerland), 15(9), 1091.
Munk, N. E., Knudsen, J. S., Comerma-Steffensen, S., & Simonsen, U. (2019). Systematic Review of Oral Combination Therapy for Erectile Dysfunction When Phosphodiesterase Type 5 Inhibitor Monotherapy Fails. Sexual medicine reviews, 7(3), 430–441. https://doi.org/10.1016/j.sxmr.2018.11.007
Cui, H., Liu, B., Song, Z., Fang, J., Deng, Y., Zhang, S., Wang, H., & Wang, Z. (2015). Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia, 47(1), 20–24. https://doi.org/10.1111/and.12216
Sullivan JF, Campbell KJ, Lipshultz LI. Combination Therapies for Erectile Dysfunction—A Synergy of Modalities Holds the Key. JAMA Netw Open. 2021;4(2):e2037292. doi:10.1001/jamanetworkopen.2020.37292
