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THE FIRST EVER ED SOLUTION TARGETING YOUR BRAIN AND BODY.

THE FIRST EVER ED SOLUTION TARGETING YOUR BRAIN AND BODY.

THE FIRST EVER ED SOLUTION TARGETING YOUR BRAIN AND BODY.

THE FIRST EVER ED SOLUTION TARGETING YOUR BRAIN AND BODY.

THE FIRST EVER ED SOLUTION TARGETING YOUR BRAIN AND BODY.

Important Safety Information

Rugiet Ready (Sildenafil + Tadalafil + Apomorphine)

Advice for patients who have been prescribed Rugiet Ready (sildenafil/tadalafil + apomorphine):

You acknowledge that any medication dispensed by our pharmacy partner in accordance with a prescription provided by a health care provider will NOT be shipped in child-resistant packaging, and that you must KEEP OUT OF REACH FROM CHILDREN/DO NOT LEAVE IN AN AREA ACCESIBLE TO UNATTENDED CHILDREN.

THIS IS A CUSTOM PRESCRIPTION MEDICATION AND SHOULD BE SAFELY SECURED OUT OF REACH OF ANYONE OTHER THAN YOU.

STORAGE: Store Rugiet Ready in a cool, dry place at room temperature (preferably 74° F or cooler). Rugiet Ready can also be stored in a refrigerator. Do NOT leave Rugiet Ready out in direct sunlight or extreme heat (e.g. in a vehicle). If Rugiet Ready is exposed to high temperatures or body heat, it will melt. If Rugiet Ready has become soft or has melted, it can be put in a refrigerator and used once it has become firm enough to pop out of its blister pack.

Rugiet Ready is only intended for use for men 18 years and older.

Rugiet Ready is a compounded medication, and thus, although it is formulated from FDA approved active pharmaceutical ingredients, it is NOT FDA approved for safety or efficacy for any indication.

The recommended Rugiet Ready dose will be different for each individual. We will work with you to adjust the strengths to find the one that works best for you.

Take one Rugiet Ready 15-30 minutes before planned sexual activity (30 minutes is recommended for best results). Note that Rugiet Ready will not work unless you are sexually aroused.

Place Rugiet Ready under your tongue and allow to fully dissolve. DO NOT CHEW OR SWALLOW. As Rugiet Ready dissolves, the medication will be absorbed directly into the bloodstream, resulting in a faster onset than if swallowed.

It is only safe to kiss after Rugiet Ready has completely dissolved and there is none remaining in your mouth. It generally takes approximately 11 minutes for Rugiet Ready to completely dissolve.

The length of time that Rugiet Ready will last may vary from person to person. However, most men find that the effects of sildenafil last for 4-5 hours, the effects of tadalafil last for 24-36 hours, and the effects of apomorphine last for 3-4 hours after taking the medication.

The maximum recommended dosing frequency of Rugiet Ready is one dose in every 24 hours. For Rugiet Ready combinations that contain greater than 10mg of tadalafil, it should be noted that tadalafil can stay in the blood stream for up to 36 hours, and this should be taken into consideration.

Medications containing any nitrates (such as nitroglycerin, isosorbide mononitrate or isosorbide dinitrate), nitrites or alkyl nitrites (also known as “poppers”), as well as guanylate cyclase (GC) stimulators (such as riociguat), must NOT be used at the same time as Rugiet Ready, as this combination may lead to a dangerous drop in blood pressure and/or syncope (fainting).

5-HT3 (serotonin) antagonist medications used for the treatment of nausea or irritable bowel syndrome (IBS) (e.g. ondansetron (Zofran), granisetron (Kytril), dolasetron (Anzemet), palonosetron (Aloxi), alosetron (Lotronex), etc.) must NOT be used at the same time as Rugiet Ready, as this combination may lead to a dangerous drop in blood pressure and/or syncope (fainting).

You should NOT take Rugiet Ready if you have a known allergy (hypersensitivity) to sildenafil, tadalafil and/or apomorphine.You should NOT take Rugiet Ready if sexual activity is inadvisable due to your cardiovascular status.

AVOID grapefruit, grapefruit juice and excessive alcohol consumption when taking Rugiet Ready.

Use caution when taking Rugiet Ready with alpha-blockers or anti-hypertensive medications, as this may lead to a drop in blood pressure and/or syncope (fainting).

Use caution when taking Rugiet Ready with strong CYP inhibitors (such as ritonavir, saquinavir, ketoconazole, itraconazole, erythromycin), as Rugiet Ready metabolism is decreased, and this may lead to a prolonged erection, a drop in blood pressure and/or syncope (fainting).

Use caution when taking Rugiet Ready if you are predisposed to priapiasm (a prolonged erection).

Use caution when taking Rugiet Ready if you have renal (kidney) or hepatic (liver) impairment, active peptic ulcers, or a bleeding disorder.

Use caution when taking Rugiet Ready if you have been diagnosed with long QT syndrome or a prolonged QT interval, or if you take medications that prolong the QT interval. Rugiet Ready may prolong the QT interval and cause torsades de pointes (a fatal heart arrhythmia) and sudden death.

Use caution when taking Rugiet Ready if you have been diagnosed with a major psychotic disorder, have a history of psychosis, or take antipsychotic medication.

Use caution when taking Rugiet Ready if you have been diagnosed with or treated for Parkinson's disease.

WARNINGS: Rugiet Ready may cause drowsiness or daytime sleepiness (be mindful if driving or operating heavy machinery). Rugiet Ready may also affect impulse control and cause compulsive behaviors. Withdrawal-emergent hyperpyrexia and confusion may occur with rapid dose reduction or withdrawal.

You should tell your doctor that you are taking Rugiet Ready (sublingually administered sildenafil/tadalafil + apomorphine), especially if you are started on any new medications.

COMMON SIDE EFFECTS include: headache, flushing, rash, abnormal vision, cyanopsia (blue-tinted vision), dyspepsia (indigestion), oral mucosal irritation, nasal congestion, dizziness, nausea, vomiting, back pain and myalgia (muscle aches). NOTE: If any of these become a concern, please contact your doctor or call the 1-800 telephone number on your prescription label to speak one of our pharmacists.

You should STOP TAKING Rugiet Ready and seek IMMEDIATE medical attention if you experience any of the following SERIOUS side effects:

Questions and Comments

RX23 commits to resolve questions and comments about your privacy and our collection and use of your information. Individuals with inquiries or comments should contact RX23 at: customercare@rugiet.com.

RX23 310 Comal Street BLDG A Ste 270 Austin, TX 78702